免疫细胞,死亡细胞 z-bo 2020-10-07 411

　　Recent studies have shown that dead cells can disrupt the immune response and destroy the immune system's defenses against infection. A study led by scientists at the University of Sheffield showed that programmed cell death (the so-called process of apoptosis) disrupts the normal function of immune cells called macrophages. This may affect the body's patrol due to the reaction to wounds and infections. The wound site needs macrophages to prevent infection and help healing, but these white blood cells can also cause and exacerbate many human diseases, including cancer, heart disease and neurodegenerative diseases. .. The results of this study, published in "PloS Biology" (PloSBiology), show that immune cells preferentially eliminate dead cells, thereby preventing normal migration to the wound site. It shows that it weakens the immune response. This study aims to understand how immune cells are regulated and may help pave the way for new therapies that manipulate these cells to accelerate the healing process. Have. This research provides scientists with new insights into the mechanisms that control immune cells in the body, including how to reach and store damaged areas.

　　Dr. Iwan Evans from the Department of Infection, Immunity and Cardiovascular Diseases at Shefield University is one of the authors of this article. "The wrong clearance process can lead to autoimmune diseases. From cancer to neurodegenerative diseases, the immune response may increase or Causes a variety of human diseases, which is necessary to maintain human health. Study the basic biological processes that we perform every day."

　　This research aims to study the interaction between dead cells and immune cells. The fruit fly used is that it contains macrophage-like cells that are very similar to our immune cells. A new study also shows that a protein called "six micrometers below" (Simu) affects immune cells at damaged parts. Has a new role. Without this protein, macrophages will leave wounds prematurely

　　Hannah Lodi, research and research assistant author of the University of Sheffield's Infection, Immunology and Cardiovascular Disease Project is currently studying the signals that macrophages use to track dead cells, and whether they can choose between dead cells and wounds, immunity Areas with damaged cells. I want to know how to live. "