动物实验 z-bo 2020-10-08 342

　　Scientists have discovered that, compared with other animals, long-lived bats may have a long lifespan and anti-cancer potential. The research results of "Nature Ecology and Evolution" show that as age increases, the degree of DNA damage in bats is limited, and the level of DNA repair and damage removal also increases. This is limited to a certain extent by the new regulations. Genetic mediation. According to a study by an international team of scientists, the longest-lived bats (mouse bats) express unique age-related genes related to DNA repair, autophagy, immunity and tumor suppression.

　　This phenomenon has not been observed in humans or other mammals, and it can extend healthy life. In order to conduct this research, the researchers collected a few drops of blood from more than 100 wild bats in eight years of field studies, and captured, marked and released these bats. After the blood samples are quickly frozen in liquid nitrogen, high-quality RNA is extracted and sequenced, and individuals of different ages are compared. The lead author of the study, Dr. Huang Zixia of the University of Dublin, said: “We deep-sequenced approximately 1.7 trillion pairs of RNA from 150 blood samples collected from known older bats and revealed that bats are age-related. These are. Change is the healthy lifespan of bats."

　　"The age-related unique gene expression changes in bats have not been observed in humans or other mammals, and the long life span of bats, UCD professor Emma Teeling, said: "The low incidence of cancer involves Regulation and interaction of genes for DNA repair, autophagy, immunity and tumor suppression. "In order to clarify how this "anti-aging" gene expression pattern is regulated in bats, the researchers also sequenced a small regulatory gene called "microRNA" to guide the lifespan pathway of bats. Discovery control key genes .

　　Tilin said: "For example, as we age, we find that the tumor suppressor gene microRNA in bats is up-regulated, while the microRNA that promotes canceration is down-regulated."

　　These results indicate that microRNA, however, various anti-aging pathways play an important role, which may help bats extend their healthy lifespan and provide new molecular targets for future aging intervention research.

　　The research team showed that in long-lived bats, the protective telomeres on the chromosomes do not shorten with age. This new study shows that genes are at work.

　　"We have proved that bats have naturally evolved transcriptome characteristics, known to extend the lifespan of model organisms, and have discovered new genes that have not yet participated in healthy aging. It provides a new research method for extending healthy lifespan." Emma ·Professor Tai Lin said.

　　Further research on the aging transcriptome of wild long-lived bats provides a new solution for delaying the aging process.