细菌受体,机会性病原体 z-bo 2020-10-08 291

　　A study recently published by Bonnie Bassler of Princeton University and colleagues in "PLOS Pathogens" showed that they developed new mutant receptors used by bacterial pathogens. Arbitrate the induction chemical communication process. As the authors pointed out, mutant receptors can be used as therapeutic compounds to recognize and inhibit quorum sensing to meet emergency medical needs.

　　The human pathogen, Pseudomonasaeruginosa, uses quorum sensing to coordinate group behavior, including the formation of biofilms and the production of infectious agents. Quorum sensing is the key to Pseudomonas aeruginosa becoming a pathogen. It depends on the production, release and detection of extracellular signal molecules. Auto-inducible factors bind to receptor proteins and jointly activate the transcription of permanent foot sensor genes. In this new study, Bassler and his colleagues discovered, purified and identified a mutant of the Pseudomonas aeruginosa RhlR quorum sensing receptor named RhlR*.

　　It is worth noting that hlR * does not require a collaborative automatic induction program to work. Pseudomonas with RhlR* correctly forms biofilms, produces toxic factors, and can infect roundworms. Since RhlR* works independently of automatic inducers, RhlR* can perform biochemical and genetic analysis that RhlR cannot. This discovery provides new insights into the working mechanism of the quartz sensing element of Pseudomonas aeruginosa. One of the most striking is the PqsE enzyme, which together with RhlR regulates the production of toxic factors. The author believes that RhlR* is a particularly valuable tool for understanding the cell-to-cell communication and toxicity of the clinically relevant pathogen Pseudomonasa eruginosa.

　　The author said: "As far as we know, this is the first report of this quorum sensing receptor. It works without a chaperone auto-inducing molecule, opening up a new way to study the toxicity of Pseudomonas europaea Possibly, and European Pseudomonas is an important pathogen in the world.