乳腺癌,免疫系统 z-bo 2020-10-08 321

　　Immunotherapy has changed the treatment of cancer, but its success has been limited due to complex and confusing reasons. Especially for breast cancer, few patients can receive immunotherapy, and most patients have little effect.

　　However, in a preclinical study led by the Duke Cancer Institute, researchers listed possible ways to improve these results by exposing breast cancer tumors to the human immune system. In this study recently published in Nature Communications, researchers found that intracellular enzymes are involved in the regulation of breast cancer growth and spread. In mice, they showed how to turn off enzyme activity, allowing T cells to launch an immune attack. Inhibiting the activity of this enzyme will reduce the ability of macrophages in the tumor to block the immune attack of cancer cells and promote the production of chemicals, thereby attracting more anti-cancer T cells into the tumor. Dr. Donald McDonald, Director of Pharmacology and Cancer Biology, said: "It turns out that it can be done. "Basically, tumors can be exposed to the immune system. "MacDonald and his colleagues (including the first author and collaborator Luigi Lasiobi, MD) said that the kinase called CaMKK2 is a macrophage in human breast tumors. It is reported that it is highly expressed. ... They conducted a series of exploratory studies and found that the molecule could be used as a target for the treatment of breast cancer. They collaborated with colleagues at the University of North Carolina at Chapel Hill (University of North Carolina at Chapel Hill) to develop a new drug, The drug can inhibit the growth of human breast tumors in mice.

　　McDonnell said: “This molecule not only inhibits tumor growth and increases the accumulation of tumor-killing T cells, but also reduces the tumor’s ability to suppress T cell activity. I still can’t drink. Now I can drink both.”

　　McDonnell said that he is doing more research to obtain data on breast cancer treatment in the next 18 months. Yes patients undergo clinical trials.