肥胖症 z-bo 2020-10-08 284

　　Obesity affects more than 40% of adults in the United States and 13% of the world's population. Obesity is related to many other diseases, including cardiovascular disease, diabetes and fatty liver disease, making it one of the most difficult to treat.

　　Recently, researchers at the University of Virginia discovered a mitochondrial uncoupling agent called BAM15, which can reduce fat in mice without affecting food intake, muscle mass or body temperature. In addition, this molecule reduces insulin resistance and has a beneficial effect on oxidative stress and inflammation. Mitochondria are often called cell power plants and are responsible for the production of ATP. ATP acts as the energy currency of cells, promotes body movement and other biological processes, and helps the body to function normally. In order to make ATP, it is necessary to burn nutrients in the mitochondria and build up proton energy (PMF). PMF is produced by a proton gradient that has a high concentration of protons outside the inner membrane and a low concentration of protons in the matrix or inner space of the inner membrane. Each time a proton passes through an enzyme called ATP synthase embedded in the membrane, the cell produces ATP. Therefore, the oxidation or combustion of nutrients is related to the synthesis of ATP.

　　" Therefore, drugs that lower PMF can increase respiration. Mitochondrial uncouplers enter the mitochondria to help cells increase respiration and effectively change intracellular metabolism. Because you can exercise, you don’t have to exercise.

　　Researchers who can burn more calories know that these molecules can change the metabolism of cells, so it is expected that through a series of mouse studies using drugs, the researchers are non-toxic on high doses of BAM15 and will not affect the brain bloating.