新冠病毒,糖尿病 z-bo 2020-10-08 382

　　Tim Holstein of the Holstein University Hospital in Kilschleswig believes that the sudden onset of diabetes may be related to a viral infection. For most people with type 1 diabetes, the body's immune cells usually suddenly start destroying pancreatic cells (cells involved in the production of the hormone insulin). In the case of Gnadt, Holstein suspects that the virus has destroyed his cells because his blood usually does not contain immune cells that destroy beta-cell islets.

　　People already know that diabetes is the main risk factor for the development of COVID-19, and people with diabetes are more likely to die. "If you are infected with COVID-19, diabetes is fatal," said Paul Jimmet, who studies metabolic abnormalities at Monash University in Melbourne, Australia.

　　At present, more and more researchers believe that diabetes is not only more susceptible to coronavirus infection. , And this virus can also cause diabetes in some people, Zimmet is one of them. "The diagnosis itself is an epidemic, such as COVID-19. These two epidemics may conflict. People infected with SARS-CoV-2 naturally develop diabetes. Dozens of COVID-19 patients have already experienced it when they arrive in the hospital. Very high blood sugar level. It has reached very high blood sugar and ketone levels. These glucose and ketones are deposits in the liver. If the body cannot produce enough insulin to break down sugar, it will use ketones as an alternative fuel., You It may be necessary to seek hypotheses from most of the evidence," Jimmet said. The researchers also cited other evidence. Various viruses, including those that cause severe acute respiratory syndrome (SARS), are associated with autoimmune diseases such as type 1 diabetes. Many organs involved in blood sugar control are rich in one. SARS-CoV-2 is a protein called ACE2, which can infect cells.

　　The latest clue comes from a pancreas culture experiment conducted in a small laboratory last week. This study shows that the virus can control blood sugar by destroying it, and the cells cause diabetes.

　　However, other researchers are cautious about this suggestion. Naveed Sattar, a metabolic disorder researcher at the University of Glasgow, UK, said: "We need to pay close attention to the incidence of diabetes in people with a history of COVID-19 and determine its incidence. Whether the incidence exceeds the expected level."

　　Abd Tahrani, a clinical scientist at the University of Birmingham in the United Kingdom, said that researchers need stronger evidence to establish the relationship between the two: "A well-structured epidemiological cohort study is needed. Need to conduct mechanism and experimental research."

　　diabetes database

　　The initiative is in progress. Earlier this month, an international team of scientists including Jimmet collected COVID-19. These people have no history of diabetes or blood sugar control problems. Information about patients with hyperglycemia from doctor Stefan Bornstein of the Dresden Institute of Technology, Germany

　　also participated in the establishment of the database and said that this situation is slowly emerging. I want to know whether it will induce the sudden onset of diabetes in patients with SARS-CoV-2, type 1 diabetes or new type diabetes COVID-19 and become a permanent disease. I want to know whether this virus will cause the developed type 2 diabetes, people will suffer Diabetes

　　Research on pancreatic organoids shows that SARS-CoV-2 is pancreatic tissue. Stem cell biologist Chen Shuibing and her colleagues at Weill Cornell Medical College in New York have demonstrated that this virus can infect alpha and beta cells in organoids. Some of them die, beta cells produce insulin to lower blood levels, and alpha cells produce glucagon to raise blood pressure. Chen proved that this virus can pass experiments. It directly kills or induces an aggressive immune response, destroys the function of important cells related to diabetes,

　　The virus also attacks the cells of the pancreas and liver organs transplanted into mice. When the liver senses insulin, it stores sugar and releases it into the blood. It is a very important organoid. Studies have shown that SARS-CoV-2 can cause or exacerbate diabetes. Taharani emphasized the existential argument, but the thesis itself, immunologist Shane Gray of the Gavin Institute of Medical Research in Sydney, Australia, said that this is not enough to prove the relationship between the two, and the reality may be better than some scientists thought. To be complicated. Say there is sex. He said the virus can cause extreme inflammation, impairing pancreas perception and glucose release. Insulin's ability to detect hormones in the liver and muscles is weakened and can lead to diabetes. Sartre said fatigue and muscle atrophy caused by severe infections may also pose a risk to pre-diabetic patients. The investigation revealed what happened.