胰岛素,肝脏疾病 z-bo 2020-10-08 313

　　In a recent study, researchers at Yale University showed a correlation between non-alcoholic fatty liver and liver insulin resistance. The report, published in the journal Cell Metabolism, will pave the way for the treatment of type 2 diabetes and other related metabolic diseases. In the United States, non-alcoholic fatty liver is the most common chronic liver disease, which is characterized by the accumulation of harmful fats in the liver. The disease may be caused by excessive intake of calories and is closely related to many metabolic abnormalities (such as obesity, high triglyceride levels and insulin resistance), which is a sign of type 2 diabetes.

　　However, the molecular link between fatty liver disease and hepatic insulin resistance has been heatedly discussed. Earlier, scientists identified two different lipids (diglycerides and ceramide) as potential links between fatty liver disease and liver insulin resistance. Senior authors Gerald Schulman, George. Kaugil, Professor of Medicine (Endocrinology) and other scientists have developed a method to measure the effects of two lipids on liver cells. They found that mice that accumulate diacylglycerols in the liver developed insulin resistance in the liver. In the liver, the accumulation of diacylglycerol in the progenitor cell membrane induces insulin resistance by inducing the interaction between the protein anchored in the progenitor cell membrane and the insulin receptor, and insulin regulates metabolism. The report says it is necessary to do so. Schulman's laboratory has studied the molecular pathways identified in current research as possible regulators of many metabolic disorders. Laboratories are already developing drugs for this approach, and hope to resist the metabolic disorders associated with insulin resistance in various organs and tissues.