Loss of special kinases in the liver may induce type 2 diabetes

  In a recent research report published in the international journal "ProceedingsSiONationalAcademyofSciences", scientists from Centennial College and other institutions found that stinging neurokinase 2 (SphK2, stinging neurokinase 2) or these symptoms are symptoms of early type 2 diabetes , And related to it. The results of these studies may help researchers develop new therapies for treating diabetic patients. The researchers said that the SphK2 enzyme is very important for the body's blood sugar regulation process. After conducting research using a mouse model, the researchers found that the absence of SphK2 enzyme in the liver promotes the accumulation of the fat product sphingosine and damages the liver.

  Insulin can signal glucose, liver and muscle cells take up glucose from the blood. Insulin resistance refers to the inability of cells to respond correctly to insulin, which can be induced by insulin. 2. Because the body's blood sugar level cannot be reduced sufficiently. The outbreak of diabetes. Researcher Qi said that the results of this article show that the SphK2 enzyme is an important participant in the human insulin regulation process. In a later stage, we will use genetic or pharmacological methods to conduct a more detailed study on the SphK2 enzyme and sphingosine. If we can help the body's blood sugar return to normal to observe changes in the body, it is expected to help control insulin resistance and diabetes patients.

  Currently, about 1.8 million people suffer from diabetes. Diabetes is also associated with short life expectancy, blindness, disconnection, increased risk of heart disease and decreased quality of life. This research is very important, and later researchers are based on this article. The research results have been studied in depth to develop new methods that can help treat diabetes and improve the quality of life of patients.