动物实验 z-bo 2020-10-09 305

　　In a recent animal experiment study, scientists at the Sanford Burnham Press Institute of Medical Discovery reduced the aggressiveness of tumors in mice by blocking the structure of the nuclear pore complex. It is a large channel that controls the flow of substances into and out of the nucleolus.

　　The author of the article, Dr. Maximiliano D'Angelo, said: nuclear pore complex. Our research proved for the first time that cancer cells can be selectively killed by preventing the formation of these nuclear “channels”. Therefore, targeting nuclear transport mechanisms is a promising cancer treatment strategy. D'Angelo hopes to provide a safe way to treat a variety of cancers by targeting the pore complex.

　　In this study, D'Angelo and his team tested this hypothesis by transplanting human tumor cells into mice that cannot form nuclear pore complexes. The authors tested three types of tumor cells: melanoma, leukemia, and colorectal cancer. The scientists found that the tumors in all these mice were very small and the tumors grew slowly. Scientists have proven that their method is effective and are trying to find a drug that can prevent the formation of nuclear pore complexes. This work was done at the Chemical Genomics Center in Sanford Burnham Prebys.

　　D'Angelo said: "In addition to helping cancer patients, we also envision that this drug candidate can be used to prevent drug resistance that occurs when tumors use certain drug-resistant drugs." Because it is difficult to adapt tumors to the affected environment, this drug May help some treatments be effective in the long term. "