肥胖症 z-bo 2020-10-09 317

　　Research by scientists at the University of Copenhagen has shown that obesity is a brain-related disease. Specifically, because genetic mutations affect the way the brain processes sensory information and regulates diet and behavior, some people are at increased risk of obesity. In the past decade, scientists have discovered hundreds of different genetic mutations that increase a person’s risk of obesity. However, there is still much work to be done to understand how these mutations turn into obesity. Scientists at the University of Copenhagen have now identified the human cell population involved in the development of this disease.

　　The author of the article, Associate Professor TuneHPers at the University of Copenhagen, said: "Our results provide evidence that the external biological processes of traditional organs (such as fat cells) studied in obesity research play an important role." The results were published on elife . "

　　"We have identified the types of cells in the brain that regulate the processing of memory, behavior, and sensory information related to disease development. Further research on these areas of the brain has revealed me. You can see why some of us are more prone than others. obesity."

　　This discovery was achieved by developing a calculation tool that combines two different data sets. , Related research data from the entire genome of about 450,000 people. The data compares people's health and physical attributes (such as weight) with their own genome. Obese patients have a series of common inheritance. The second group is the single-cell RNA sequencing data of more than 700 different types of mouse cell populations. Different cells are different parts of the genome. This data set contains genetic fingerprints unique to each cell population because it can be expressed. Researchers have integrated these two data sets with 26 gene mutations closely related to obesity. We found that the brain plays an important role in obesity by regulating the body's energy requirements. It is done by processing signals from the body about energy storage and food intake, as well as external signals (such as the appearance and smell of food).

　　New findings indicate that the risk of obesity affects the body’s sensory stimulation and it has been shown to be caused by cell populations that directly affect diet and behavior. They also discovered specific brain cell types that support learning and memory in obesity. "The next step is how traditionally known defects in the part of the brain that regulate the integration of memory and sensory signals make us obese. Investigate whether it increases obesity. Increasing evidence shows that obesity is more complicated than previously recognized. Obesity cannot simply A simple problem due to lack of willpower.