动物实验 z-bo 2020-10-09 280

　　Recently, researchers at Washington State University have discovered an important genetic factor through animal experiments that allows adult skin to repair itself like the skin of a newborn baby. This discovery is essential to better treat skin damage and prevent certain skin aging processes.

　　Researchers discovered that molecular switches in the skin of mice can control the formation of hair follicles during the first week of life. After the skin is formed, the switch is almost closed and remains closed in adult tissues. When special cells in adult mice are activated, the skin can heal wounds without leaving scars.

　　The author of the article, Driskell, associate professor of molecular biology at Washington State University, said: "You can use the innate ability of young new skin to regenerate this ability and transfer it to the old skin. In principle, this regeneration is possible. "

　　Compared with other organisms, the regenerative ability of mammals is still unclear. WSU’s research shows that the secret of human regeneration can be discovered by studying our own early development.

　　Driskell said: "You can find inspiration for other creatures, but you can also learn to regenerate by observing yourself." "As we grow, we are undoubtedly the new organization in our lives.

　　The Driskell team used a new technology called single-cell RNA sequencing to compare genes and cells in developing and adult skin. During skin development, they discovered that a transcription factor called Lef1 is related to papillary fibroblasts. When WSU researchers activated the Lef1 factor in the skin of adult mice, the regenerative capacity of the skin was improved, scars were reduced, and new hair follicles were grown.

　　After learning about the work of Dr. Michael Longaker of Stanford University, Driskel first thought of the ability to repair the skin in the early life of mammals. When Longaker and his colleagues performed emergency life-saving operations in the womb, they observed that the babies were born without surgical injuries.

　　Driskell said that to apply this latest mouse discovery to human skin, a lot of work needs to be done. The WSU research team will continue to work hard to understand how Lef1 and other factors repair the skin.