过敏疫苗,HLA-DR1基因 z-bo 2020-10-09 370

　　Whether you are allergic or not is highly genetically dependent. This is the main conclusion of a new study recently published on EBioMedicine. The research was led by Professor Winfried F. Pickl from the Institute of Immunology at the Medical University of Vienna. They found that the HLA-DR1 gene and allergen-specific reactive T cells play an important role in allergy to abnormal plants. Scientists have long believed that HLA molecules play an important role in autoimmune diseases, chronic infections and allergies.

　　In this study, the researchers found that among the four mouse models, only the model with HLA-DR1 is allergic to Magwart, and the number of active reactive T cells that require allergen specificity are regulatory T cells. I found transcendence for the first time. Pickl explained: "The result is the formation of asthma and pathogenic allergy-specific immunoglobulin E." Magwater is introduced through the respiratory tract, just like people are usually exposed to the outside. The researchers used a humanized mouse model. Pickl explained: "These mice have human T cell-specific allergen receptors and HLA molecules on the surface of antigen-presenting cells. The new model is the first model that reflects the human state." An immunologist at the University of Vienna School of Medicine It can be further found that the use of T cell proliferation factor interleukin 2 helps to stimulate regulatory T cells, thereby preventing allergic asthma.

　　Asthma vaccine is imminent

　　"Now, we understand the process of allergies at the molecular level, which enables us to better prevent and treat allergies in the future," Pickl said. .. This laid the foundation for the future development of anti-allergic vaccines. By identifying HLA molecules, doctors can know whether the baby will have an allergic reaction in the future and treat it as soon as it is needed. "This model mainly studies Magwart's allergens, but you can also study all other allergens in this model."