前列腺癌 z-bo 2020-10-09 426

　　After stimulating a patient with advanced prostate cancer with a large amount of testosterone, the tumor mass in his body miraculously disappeared. At the same time, the tumor progression of the other 46 patients who participated in the small medical trial was significantly reduced.

　　This preliminary result was unexpected. After all, prostate cancer cells use testosterone as fuel, and most current treatments limit hormone levels to kill tumor cells. Samdenmead of Johns Hopkins University School of Medicine conducted a small study of 47 men with advanced prostate cancer. These patients are highly resistant to the latest hormone therapy, enzaltamide and avirateron. Resistance. For a long time, the goal of limiting tumor growth by suppressing testosterone levels has been achieved, but tumor cells quickly become resistant. In addition, some studies have shown that high levels of hormone stimulation may play a role in tumor resection. Therefore, the researchers repeatedly stimulated high concentrations of testosterone, and immediately carried out the so-called "second-line treatment" to limit testosterone levels for at least three cycles. Specifically, cancer patients receive high doses of testosterone every 28 days to prevent the drug from producing endogenous testosterone in the intestine. By detecting the volume of the tumor, the authors found that this new treatment method can effectively reduce the volume of the tumor. Among them, the male patient miraculously disappeared after 22 rounds of treatment!

　　This result has not been peer-reviewed and is not completely acceptable. In addition, clinical trials are still in progress, so far there is no clear conclusion. However, the results not only proved the effectiveness of hormone therapy, but also sensitized cancer cells to conventional therapeutic agents. So far, researchers have not understood the molecular mechanism behind the treatment, and speculated that this may be related to blocking the process of cell division. In addition, large amounts of testosterone seem to cause DNA damage.

　　Finally, I hope this therapy can provide new ideas for the treatment of prostate cancer.