动物实验,补骨脂提取物 z-bo 2020-10-12 342

　　Objective: To study the toxicity of different extracts of Psoralen to rats by oral administration, and provide a safety basis for its clinical application.

　　Method: 112 SD rats were divided into 8 groups according to gender and body weight: control group, daylight crude drug group, daylight penetration high, low dose group, daylight penetration group high, low dose, high dose. The dose and low dose of sunlight penetration [coarse group (coarse dose) 3 g/kg body weight, high dose and low dose (coarse dose) 6 and 3 g/kg body weight in other dose groups], 14 animals in each group. The drug was administered continuously for 4 weeks. After the administration, fasting and pumping water for 12 hours, drawing blood to detect related blood biochemical indicators, dissecting and weighing the organs to calculate the organ coefficient and measuring the MDA of liver tissue.

　　Results: Compared with the diet group, the liver organ coefficient, ALP and MDA of the dietary drug group were significantly increased, while the thymus organ coefficient and T-AOC were significantly decreased; the diet group was the liver of the hypotonic solution group. The organ coefficient, T-AOC and ALT of the high-dose sunbathing infiltration group were significantly increased, the liver organ coefficient and MDA were significantly increased, while the T-AOC value of female rats was significantly decreased. There was no obvious liver in the low-dose drug residue group. , Nephrotoxicity; there is no significant difference in the upper exudate group.

　　Conclusion: The upper layer of the sunbathing agent is safer than the lower layer of the sunbathing agent, but according to the results of the active ingredients, the permeable lower layer is more suitable for human medicine.