动物实验,代谢化合物 z-bo 2020-10-12 281

　　In a study recently published in Celleports, researchers used a small amount of metabolic compounds that can reverse the aging process of eggs and successfully improve the fertility of older female mice. This brings hope to some women who have difficulty getting pregnant.

　　This study led by Professor Hayden Homer of the University of Queensland in Australia found that non-invasive treatment can maintain or restore the quality and quantity of eggs, thereby reducing the biggest obstacle to pregnancy for elderly women. Find. As we age, the quality of eggs decreases as the level of special intracellular molecules necessary for energy production decreases.

　　Professor Homer said: “High-quality eggs are essential for a successful pregnancy because they provide almost all the components needed by an embryo. To this end, we studied the "precursor" compound (which is used by the cell). Whether to use To make molecules) can reverse the process of reproductive aging. The names of the molecules and "precursors" cited in this study are NAD (nicotinamide adenine dinucleotide) and NMN (nicotinamide mononucleotide). Glycolic acid Professor Homer explained that the fertilization rate of mice began to decline at about 1 year old, which was caused by defective egg quality, similar to egg changes in elderly women.

　　Professor Homer said: “Add a low dose of NMN to the drinking water of mice and treat them for 4 weeks. During the regeneration test, the egg quality of the mice was significantly restored and the number of births was also restored. A significant increase "Professor Homer said that poor egg quality is the primary challenge facing human fertility in developed countries.

　　He said: "This is a serious problem because more and more women are getting pregnant as they get older, and a quarter of Australian women receiving IVF are over 40 years old. Seeding does not improve the quality of the eggs. Therefore, Currently, the only feasible solution for older women is to use eggs donated by younger women."

　　This study shows that oral NAD enhancers can restore egg quality and thus female reproductive function. It is much less invasive than in vitro fertilization. However, despite the promising prospects of these drugs, it should be emphasized that their potential benefits need to be tested in clinical trials.

　　This research was conducted in cooperation with the University of New South Wales, Australia.