动物模型,新冠肺炎 z-bo 2020-10-13 361

　　In order to better understand the pathogenic mechanism of the new coronavirus (SARS-CoV-2) and to screen effective prevention or treatment methods, there is an urgent need for a suitable animal model of infection and disease.

　　The Kunming Institute of Zoology, Chinese Academy of Sciences has conducted research on the establishment of a new type of coronavirus infection model, which is a closely related species of primates. The researchers selected trees of various ages to infect COVID-19, including adult trees around 1 year old and older trees 5-6 years old. Lung images, viral load, blood routine, biochemical and histopathological analysis were performed on different days after inoculation of the trees. The results of the study show that the bark can be infected with COVID-19 virus. X-ray examination can show images of lung invasion of most infected trees. Three, five and seven days after infection, viral RNA can be detected in the lung tissue of the infected tree, including elevated aspartate aminotransferase (AST) and urea nitrogen (BUN) levels, blood routine and serum biochemical reagents. The parameters will also change. Three days after infection, histopathological staining of lung tissue in the adult and elderly groups showed thickening of the alveolar septum and interstitial hemorrhage. In terms of peak virus loading, there were some differences between the trees of the two different age groups.

　　This study shows that Chinese trees can be used as model animals to study the pathogenic mechanism of SARS-CoV-2 and the evaluation of drugs and vaccines. Associate researcher Xu Ling and associate researcher Yu Dandan of Kunming Institute of Zoology are co-authors, and researcher Zheng Yongtang and researcher Yao Yonggang are co-authors. This work was funded by the Ministry of Science and Technology, National Natural Science Foundation of China, Chinese Academy of Sciences and Yunnan Science and Technology Bureau.