肥胖模型,高糖高脂 z-bo 2020-10-16 279

　　Objective: To explore the effect of high-fat and high-sugar diet on fat distribution and blood biochemical indexes of Parmani pigs.

　　Method: 14 Bama mini-pigs, 8 experimental groups, type 2 diabetes-sensitive mini-pigs raised in our laboratory, fed a high-fat and high-sugar diet for 30 weeks, and the control group 6 were fed a regular diet. After 30 weeks, body shape coefficients, CT scan fat content and blood were collected as biochemical indicators to compare the differences between the experimental group and the control group.

　　Result: After 30 weeks of high-fat and high-sugar diet, there were significant differences in body weight, body mass index (BMI) and total fat content between the experimental group and the control group (P\u003c0.05). Visceral fat content is very significant (P\u003c0); blood biochemical indicators of insulin, total cholesterol, high-density lipoprotein cholesterol and triglycerides are very different from those of the control group (P\u003c0). .01), low-density lipoprotein cholesterol is significantly different from the control group (P\0.05). In addition, the serum protein and creatinine of the experimental group of Bama miniature pigs are significantly different from the control group (P\u003c0.05), and uric acid and urea are significantly different from the control group (P\u003c0.01). The minipigs in the group had kidney damage.

　　Conclusion: High-fat and high-sugar diet will cause fat accumulation in Parmani pigs, especially visceral fat accumulation. Blood biochemical indicators indicate hyperlipidemia and renal insufficiency.