T细胞抗癌,T细胞 z-bo 2020-10-16 292

　　According to a new study published in the journal eLife, when T cells in the immune system find and recognize a target, they release chemicals to attract more T cells and gather to alleviate this threat.

　　Discover the behavior of the colony and the chemical attractant that immune cells direct the colony to the tumor. One day scientists will develop new cancer treatments that can strengthen the immune system. May be useful. This is especially important for solid tumors. So far, solid tumors have not responded to current immunotherapy as well as blood cancers.

　　Main author Jorge Luis GaleanoNi? o Status: "Scientists used to believe that T cells that kill cancer can identify tumors by randomly searching or tracing chemical traces produced by other intermediate immune cells. To further research on this, I want to see if it is correct or if T cells pass Another mechanism recognizes tumors."

　　The research team used a 3D tumor model and a mouse model grown in the laboratory and used it. T cells that kill cancer remain in tumor cells, which have been shown to exist independently of intermediate immune cells. When T cells find and recognize a tumor, they send out chemical signals to attract more T cells and sense the signal through a receptor called CCR5, which triggers a group response. GaleanoNi? o Status: "These cells regulate the migration process, reminding people of bee colonies observed in certain insects or another group of immune cells called neutrophils. Injuries and pathogens react."

　　After confirming the results using a computer model, the research team genetically modified human cells called chimeric antigen receptor (CAR)-T cells and proved that they were swarming. 3D glioblastoma tumors grow in the laboratory.

　　CAR-T cells are currently used to treat certain types of blood cancers. However, the new findings indicate that it is also possible to train these cells to attack solid tumors.

　　This is a basic research, but at an early stage, the cluster mechanism can be used to target CAR-T cells to solid tumors. This enhances immunotherapy and may be able to penetrate and destroy these types of tumors more effectively. It is also important to determine whether demographic mechanisms are beneficial in reducing autoimmune conditions or overheated T cell responses to viral infections after transplantation. "