酒精性脂肪肝 z-bo 2020-10-16 335

　　Scientists from the University of Liverpool and other institutions in the "American Journal of Gastroenterology and Hepatology" published two new research reports, through research to determine the risk factors associated with the development of alcoholic fatty liver. Alcoholic fatty liver is a symptom of liver tissue scarring caused by the human body ingesting alcohol. Previously, researchers have clarified through research why some people with alcoholism develop slow cirrhosis, and why not. In this study, the researchers conducted two studies on patients diagnosed with alcoholic fatty liver and compared them with patients with similar drinking history but no liver damage.

　　In the first study, the researchers analyzed a variety of risk factors, including drinking style, preferred alcoholic beverages, and other non-alcoholic lifestyle choices related to cirrhosis, hepatitis, diabetes, and elevated BMI. This is common in patients with liver cirrhosis, and there is evidence that people without liver damage are more likely to be wine lovers, coffee lovers, smokers, and cannabis users. In the second study, the researchers used genome-wide studies to identify genes that increase the risk of cirrhosis in the population. This method allows you to search for single nucleotide polymorphisms (SNPs) in a single genome. And analyze. Everyone’s body has millions of SNPs, but if a specific SNP occurs more frequently in people with special diseases than in people without diseases, this may explain the reason. Do not. The root cause behind this difference. In this article, the researchers revealed a new genetic link between the FAF2 gene and alcoholic fatty liver. This gene is involved in fat metabolism in liver cells. This may also explain why individuals are at risk of high fatty liver.

　　The results of these two studies are consistent with the results of the second batch of UK Biobank studies, which may prove the credibility of the research results. Researcher Sir Munir Pirmohamed said the findings can help improve research. People's understanding of the etiology of refractory liver disease, these genetic and non-genetic factors, may also help explain why some people are prone to cirrhosis. Improving the understanding of the risk factors of alcoholic fatty liver may provide researchers with new ideas to assess the disease level of patients and develop new targeted therapies for alcoholic fatty liver.