预防轮状病毒感染,轮状病毒 z-bo 2020-10-16 276

　　In the latest research report published in the International Journal of Scientific Immunity, scientists at Georgia State University and other institutions can treat and prevent rotavirus infections by combining two substances secreted by the human immune system. It was discovered through research. At the same time, it may be able to treat other viral infections that target human epithelial cells. Rotavirus can cause severe, life-threatening diarrhea. It may also cause gastrointestinal discomfort in adults. Thousands of children die every year, especially if the rotavirus vaccine is effective. In China, this virus is an RNA virus that mainly infects intestinal epithelial cells. In this study, the researchers identified special substances in the cytokine category: Interleukin 18 (IL-18) and Interleukin 22 (IL-22). When the human body detects the presence of special proteins in the whip-like appendages of bacteria, it produces IL-18 and IL-22.

　　In the article, the researchers revealed how these cytokines inhibit rotavirus infection. When IL-18 and IL-22 are used to treat mice, these cytokines promote each other's expression, but when used alone, they interfere with rotavirus replication, thereby activating receptors on intestinal epithelial cells. The mechanism is different. These mechanisms of action can quickly and completely eliminate rotavirus infection even in hosts with significantly impaired immune system function. also the same. In addition, this treatment strategy can effectively treat norovirus infections. Researcher Andrew Gewarts said that the study in this article proposes a new method to effectively eliminate viral infections, especially for those viruses that infect intestinal epithelial cells. Research results show that the combination or combination of IL-18 and IL-22 can effectively treat viral infections of short-lived epithelial cells with high target turnover. Subsequently, researchers will continue to in-depth research and develop new and more effective targeted therapies for diarrheal virus infections (such as rotavirus).