HIV z-bo 2020-10-17 388

　　Recently, researchers at the University of California, Davis discovered through research that HIV is hidden in the intestine and may not be eliminated by the body’s immune system. After studying the Simian Immunodeficiency Virus (SIV), the researchers produced cellular pain cells with a special intestinal tract that responded early to the virus invasion and produced interleukin-1β (IL-1β).

　　It can also trigger the enteritis response. Related research results were published in the international journal "PLoS Pathogens". In the presence of SIV virus, IL-1β can promote the destruction of intestinal epithelial cells and protect the human body from SIV infection. The researchers pointed out that the biggest obstacle to the complete elimination of the virus and the restoration of human immunity is the existence of intestinal stability. With the HIV virus library in China, researchers have discovered the early invasion of the virus and intestinal infection. I know very little about how to build a virus database. Researcher Satya Dandekar said that he wanted to find out what caused the HIV virus to invade the intestines, cause inflammation and kill immune cells. This study found that Panes cells may be the first sensor of HIV infection in the intestine. Second, it can cause enteritis, tissue damage and the spread of viral infections. Our findings also provide new ideas for identifying potential targets and new intervention strategies for preventing early viral infections.

　　In this article, the researchers first tested a series of intestinal SIV cells infected for 2.5 days. The inflammatory response to the virus mainly occurs in the intestinal wall. Researchers found that IL-1β can reduce tight junction proteins. The latter is essential to create a protective barrier against viral infections for the intestines. With the deepening of research, it was also found that the inflammatory response of IL-1β may begin in Panes cells. In the early stages of viral infection, Panes cells become sad when they sense SIV infection and IL-1β production. This is related to the damage to intestinal epithelial cells. Researchers have added the probiotic Lactobacillus plantarum to the intestine to eliminate the intestinal damage caused by the decrease in IL-1β levels, thereby alleviating inflammation and repairing intestinal tissues. Said it can be speeded up. Therefore, the use of the synergy of parasitic bacteria can effectively prevent the early infection and spread of the virus. Of course, understanding the role of probiotics in the intestinal immune response is also very important for the development of treatments for viral infections.