老年痴呆症 z-bo 2020-10-17 383

　　Certain epigenetic changes (mechanisms that affect gene expression through environmental factors) are closely related to the pathological manifestations of the disease in the brain of patients with Alzheimer's disease. Two independent and complete Epigenome Association research reports published online on Nature-Neuroscience point out the above conclusions. This means that there are new goals for studying the neurobiological principles of Alzheimer's disease and developing potential treatments.

　　PhilipDeJager, David Bennett and others belong to the group, while Jonathan Mill and others belong to the group. Two groups of scientists described and compared changes in DNA methylation in the affected brains of approximately 1,200 patients across the entire genome. Compared with the healthy control group, 11 and 7 gene regions were found in the two groups of horses and horses, respectively, which may show increased or decreased methylation levels (methylation indicates DNA expression). This is one of the epigenetic changes shown. These gene regions are closely related to the symptoms of Alzheimer's disease, including amyloid plaque hyperplasia, protein production common in Alzheimer's disease, and clinical features of neurodegeneration. Four of these genes (ANK1, RHBDF2, RPL13, and CDH23) were found in both study sets, indicating overlapping results.

　　The exact cellular functions of these genes are still unknown, but these conclusions mean that there are new goals for studying the neurobiological principles of Alzheimer's disease and developing potential treatments. I will. Since DNA methylation is an epigenetic change, these changes may be the cause of age-related neurodegenerative diseases (such as Alzheimer's disease), and also suggest the mechanism of disease sporadic types.