糖尿病基因 z-bo 2020-10-17 388

　　Researchers from the Swiss Federal Institute of Technology in Lausanne and the Swiss Federal Institute of Technology in Zurich recently discovered through research that humans and mice share the genes for diabetes. Related research was published in the international journal Cell Metabolism.

　　In this article, the researchers conducted a genome and phenotype study on 183 mice. Researcher Johan Auwerx said that the effects of environmental factors can be assessed by comparing the metabolic status of twin mice with different growth and diet conditions. Its effect on the expression of certain genes in the body provides specific data to clarify the clinical characteristics of mice and their impact on disease development. Combining genotype and phenotype research can greatly accelerate the speed of scientific research. In this study, the researchers added a new type of quality analysis technology to the analysis of genotype and phenotype. Thousands of proteins in the samples were quantified and a special proteomics database was established. By combining relevant data from the mouse genome, phenotype, proteome and metabolome, the researchers identified specific genes related to type 2 diabetes on the mouse chromosome 2.

　　The important role of high-fat diet mice in the development of diabetes depends on the expression of this gene. By combining multiple levels of data, researchers have clearly classified the relationship between whether genes are turned on and diabetes risk. Further studies have shown that the level of a special metabolite 2-aminooxalate in the urine of diabetic mice is very low, and its concentration changes obviously depend on the existence of this special gene, but it depends on the mice. It has nothing to do with fat. Therefore, the researchers pointed out whether this relationship also exists in the human body of mice, so they conducted another study on diabetic patients. As a result, the level of 2-aminooxalyl phosphate in diabetic patients was high. In addition, because it is lower than in non-diabetic patients, the urine metabolite 2-aminosuccinic acid can be used to help detect whether an individual has diabetes. The research in this article may help scientists develop new diagnostic tools for diabetes and other diseases.