白血病 z-bo 2020-10-19 267

　　A research team led by scientists from Harvard University and the Massachusetts Institute of Technology compared how hematopoietic stem cells and leukemia cells consume nutrients in a new study and found that cancer cells cannot tolerate energy compared to normal cells. These results indicate that there may be multiple pathways that can target leukemia metabolism to promote cancer cell death without harming other cell types. The researchers published their work in the Cell magazine. The lead author of this paper, Dr. David Skaden, a professor of medicine at Harvard University, said: “Decades ago, it was known that cancer cells use different energy from most cell types, so hematopoietic stem cells are different from Skaden’s There may be metabolic differences between direct offspring. Maybe they are so different from cancer that they can only affect cancer without manipulating energy to destroy normal cells?"

　　Skadenesearch Group 1 hematopoietic function. Stem cells and their direct descendants, hematopoietic progenitor cells have been tested, and their differentiation ability is relatively limited. The researchers changed the way cells absorb nutrients in two ways. One is to use the glucose on/off switch, and the other is to rotate the volume dial to increase or decrease the glucose by fine adjustment. Researchers have found that turning off the glucose switch will cause the death of stem cells, and increasing the glucose dial will affect the normal energy production of offspring cells, which may be better in some respects.

　　Scadden said: "This is an interesting difference between the two types of cells. They have very different functions and different nutrient uses. No one has explained. Since then, researchers have been injured and parental hematopoiesis has occurred. We have introduced several Genes that may cause cancer in stem cells and their offspring, no matter which cell the research team started from, cancer cells can receive the same glucose treatment as normal cells. Leukemia cells were found to be sensitive to glucose on the switch and on the volume dial.

　　Ying-HuaWang (transliteration), a postdoctoral researcher in the Scadden laboratory, and the lead author of this article said: This study has found a way to distinguish the sensitivity of normal cells from malignant cells and suggests potential therapeutic prospects. "Cancer cells are different from normal cells in many ways. One is that cancer cells are locked in certain behaviors. These cells process glucose in a very unique way. This creates a unique opportunity for intervention. Normal cells will not be destroyed because They appropriately possess other cells. Energy mechanisms. We are developing drugs mainly for solid tumors. Scadden hopes that this research will open the door to industrial partners and create several new treatments. Further research is needed to determine Whether there are similar differences in the metabolic sensitivity of non-hematological cancers.