[Animal model]-What are the common fish experimental animal species?
动物模型,实验动物
z-bo
2022-04-20
598
More than 22,000 species of fish have been recorded worldwide, which is a source of endless experimental materials. Since fish live in water for life, these materials are easy to obtain, most of which are in vitro fertilization and in vitro development, such as toxicity testing, environmental monitoring, developmental biology, physiology, ecology, genetics and other experiments. Usually used as a material. It is widely used in various fields. At present, there is no uniform standard for experimental fish, most of which are used as experimental materials and can only be called "animals used for experiments." Commonly used species are:
The zebrafish is native to South Asia and is a common tropical fish. Zebrafish are slender, with adults 3-4 cm long and do not require high water quality. At present, there are about 20 types of zebrafish strains that have matured cell labeling technology, tissue transplantation technology, mutation technology, haploid species technology, gene recombination technology, gene activity inhibition technology, etc. The excellent resources of molecular mechanisms of embryonic development that have been studied have become one of the most important models of vertebrate developmental biology.
Qing Feng is a small fish born and bred in East Asia. Due to the existence of mutant individuals, it was used as a research material for genetic analysis for the first time. Qing Qiang has a partner color gene r. It is very convenient to use alleles to create a system that distinguishes men from women by skin color. Because spawning is controllable, in 1994, we sent medaka into space as a representative of vertebrates, and during the entire development process from fertilization to ontogeny, we truly realized "space breeding". It is widely used in physiology, ecology and endocrinology research.
crescent fish and swordtail are tropical fish. Crescent and swordtail fish are prone to melanoma. There are 23 species of swordtail fish, and their genera have different phenotypes and body colors. Therefore, genetic linkage studies can be carried out by crossing and backcrossing. Swordtail hybrid melanoma model is a classic model in tumor research. Swordtail fish are sensitive to various pesticides, heavy metals and other toxic substances. At the same time, it is also very sensitive to certain fish pathogens and has many mutations, such as blindness and deformation. Suitable as an animal model. The Pearl River Fisheries Research Institute has grown three kinds of swordtail fish: RR-B, RW-H and BY-F. Among them, the RR-B series products were approved at the first meeting of the third meeting of the National Aquatic Species and Improved Species Approval Committee. It is the first approved aquatic experimental animal species in China. It is aquatic environment monitoring, aquatic drug safety assessment, chemical toxicity test, animal disease test model and genetic biology research field. Red fish is a kind of of fish, mainly distributed in the south of the Yangtze River. As an experimental animal, red cru fish has the characteristics of high vitality, fast sexual maturity, strong fecundity, moderate body size, and omnivorousness. Therefore, the Department of Experimental Zoology of Hunan Nanhua University has tested red cru fish. Using hermaphrodite technology to transform into animals and establish red red fish. Inbred lines are mainly used for various scientific research, such as genetics, fertilization biology, oncology and toxicology.
