糖尿病 z-bo 2020-10-19 310

　　Recently, great progress has been made in the treatment of diabetes. Scientists have invented a method to transform human embryonic stem cells into cells that can produce and release insulin. A new technique invented by researchers at Harvard University can basically reconstruct the formation of beta cells in the pancreas that secrete insulin. When embryonic stem cells were transplanted into beta cells and placed in a mouse model, blood sugar levels quickly recovered. The researchers found that the flask contained 5 different growth media and 11 other molecules containing proteins and sugars. Embryonic stem cells become mature β cells and can be cultured for 35 days or more. Even more surprising is the ability to produce 200 million β cells in a 500 mL culture flask. In addition, the culture protocol seems to be applicable to induced pluripotent stem cells.

　　The entire research process will take 15 years. I hope these cells can be transplanted into humans in the next few years. At present, experiments with mice have been successful. Two weeks after transplanting recombinant β cells into diabetic mice, blood glucose levels in the mice quickly recovered and stabilized. At present, scientists are transplanting reconstructed β cells into primates and observing their therapeutic effects. According to data from the US Centers for Disease Control and Prevention, by 2012, 29.1 million people in the US had diabetes, accounting for 9.3% of the US population. Currently, diabetic patients mainly inject insulin to maintain blood sugar stability, but this process requires continuous monitoring and attention. Patients who cannot effectively control their blood sugar levels may eventually lose their vision, which can lead to nerve damage and heart disease.

　　Douglas Melton, who led the research, said: "Our research is expected to treat diabetes within 10 days. This breakthrough is a precedent for the treatment of chronic diseases such as diabetes. There is no obstacle, especially for patients with type 1 diabetes. The immune system of such patients actually targets the beta cells that produce insulin and destroy these cells. Therefore, Melton’s research team is trying to find a protective layer of beta cells to rebuild to ensure the safety of these cells in type 1 diabetes patients. Sex.

　　In addition, many people are opposed to the research of human embryonic stem cells, which caused some obstacles due to political and moral restrictions. Therefore, researchers are trying to rebuild beta cells together with other types of stem cells. Jose Olberholze, professor of bioengineering at the University of Illinois, said: “I think this major initiative has gone beyond the realm of insulin discovery. Insulin has saved countless lives of patients, but they cannot lead a normal life. I hope diabetics can fully Heal. I hope."

　　Hualian

　　Douglas Melton’s son was diagnosed with diabetes when he was a child, and his daughter was diagnosed with diabetes when he was 14. Currently, his son is 23 years old and his daughter is 27 years old. As a father, I am not surprised by these great advances and hope to solve the current problems and heal my child as soon as possible.