“无能”抗体有什么大用处？ z-bo 2020-10-19 259

　　The researchers found that the antibodies found in large numbers in mice were previously thought to be ineffective in helping fight infections, maintaining detection and preventing more severe self-harming kidney disease. According to the report, it may actually have played an important role.

　　This study found that an antibody called IgG1 can actually play a protective role. This antibody is produced in large quantities in mice, similar to human IgG4 antibodies. Fred Finkelmann, Professor of Medicine and Pediatrics at the University of Cincinnati and Chairman of the George McDonald Medical Foundation, said: "Some antibodies mainly collect pathogens to activate other defense mechanisms, including a group called complement. Serum proteins, and cells with surface antibody binding molecules Fc receptors will resist them."

　　Finkelman is also an immunobiology researcher at Cincinnati Children's Hospital Medical Center. Dr. Richard Strright, assistant professor of pediatrics at the University of Cincinnati and chief physician at Cincinnati Children’s Hospital, is the first author of this article.

　　Finkelman said: "Surprisingly, most of the antibodies produced by mice are IgG1, which aggregate pathogens, and their ability to activate complement and bind Fc antibodies to activate cells is relatively weak. "It has a similar antibody IgG4 and is relatively lacking in this. Kind of ability,"

　　Finkelman said. "Why have such incompetent antibodies? It produces most of these antibodies. I believe biology is powerless. Things: Antibodies work very well on bacteria and viruses. If they can be killed, it will cause inflammation and damage the production of it. The body of an animal. "For mice that cannot produce IgG1 genes, the normal mouse immune system promotes IgG1 production. The researchers tested this hypothesis by injecting possible foreign proteins and observing what happened. These genetically bred mice produced another antibody called IgG3. This affects the capillaries of the kidneys and eventually leads to kidney failure.

　　Finkelman said: "The kidneys are basically blood within a few days. By blocking the blood flow, all glomeruli in the kidneys are destroyed, and the kidneys of the mice turn yellow.

　　and injected IgG1 into mice that cannot produce this antibody. ..

　　Finkelman said: "These findings support the hypothesis of why antibodies (such as mouse IgG1 and human IgG4) were produced, and were confirmed in the absence of Fc receptors (such as complement and mouse IgG3). Antibodies are a new type of antibody. In addition, our research results show that antibodies such as human IgG4 can be used to treat diseases caused by other types of antibodies, such as gravitational muscle weakness and bullous skin diseases. Myasthenia gravis is a chronic autoimmunity. Neuromuscular diseases are characterized by varying degrees of skeletal muscle weakness. People with this disease lose the ability to contract muscles because the body produces antibodies that destroy the muscle's acetylcholine receptors." "The muscle nerves continue to produce energy and release it. The chemical acetylcholine, but there are not many receptors that acetylcholine binds to. These people are very weak and will die because they cannot swallow or breathe. There is one."

　　Finkelman said that people with hair follicular skin disease will produce some antibodies against the molecules that hold skin cells together. As a result, skin cells separate from each other and blisters. It will form.

　　"People lose a lot of fluids and are susceptible to infection. These diseases are very serious and do not work well," Finkelman said.