自闭症,维生素D缺失 z-bo 2020-10-19 412

　　The clinical manifestations of autism include behavioral disorders, immune disorders, oxidative stress changes, and even genetic abnormalities. According to medical research, vitamin D deficiency is common in children with autism. In addition to traditional calcium and phosphorus metabolism regulation, vitamin D also has immune regulation, increasing glutathione synthesis and genetic stability.

　　The clinical manifestations of pediatric neurorehabilitation autism in Jilin University Hospital include behavioral disorders, immune disorders, oxidative stress changes, and even genetic abnormalities. According to medical research, vitamin D deficiency is common in children with autism. In addition to the traditional regulation of calcium and phosphorus metabolism, vitamin D also has immunoregulatory functions, which can enhance the synthesis and genetic stability of glutathione. Feiyong Jia and Ling Shan of the Pediatric Neurorehabilitation Department of the First Hospital of Jilin University and their colleagues reviewed the research progress of the role of vitamin D in autism. Vitamins are a kind of trace organic matter necessary for humans and animals to maintain normal physiological functions. They play an important role in the growth, metabolism and development of the human body. Unlike other vitamins, vitamin D is extracted from food in a small amount, and its source mainly depends on its own synthesis.

　　Autism is also an inflammatory disease. Vitamin D plays an anti-inflammatory effect by regulating innate and acquired immunity. Studies have shown that the pro-inflammatory chemokine MCP-1 and pro-inflammatory cytokine TNF-α in the serum of children with autism are significantly increased, indicating that autism has inflammatory changes. The serum prostaglandin (prostgrandin, PG) of children with autism is significantly increased, PG has an inflammatory effect, and calcitriol inhibits the synthesis of PG and exerts an anti-inflammatory effect. F-κB participates in abnormal signal transduction in the brain of autism, and calcitriol can also exert anti-inflammatory effects by inhibiting NF-κB. In human autoimmune diseases, there are more than 160 kinds of autoantibodies.

　　Various brain-related autoantibodies have been found in children with autism, such as anti-GAD65 and anti-MAG antibodies. The level of these autoantibodies is positively correlated with the severity of autism. This shows that autism also has autoimmune problems. Recent studies have shown that serum anti-MAG antibody levels in children with autism are negatively correlated with 25(OH)D levels. Therefore, vitamin D supplementation may reduce autoantibodies in autism. The anti-autoimmune effect of vitamin D can explain the relationship between vitamin D deficiency and the prevalence of various autoimmune diseases. Vitamin D supplementation can increase the proportion of regulatory T cells in the body, produce immune tolerance, and restore normal brain function. Oxidative stress is a pathological process in which the body's antioxidant capacity is reduced, leading to excessive production of active oxygen in the body or (and) increase in active oxygen in the body, thereby causing oxidative damage to cells. direction. Do it.

　　According to reports, vitamin D can directly up-regulate several antioxidant genes, such as thioredoxin reductase and superoxide dismutase. Both are involved in the antioxidant and detox process. Thioredoxin reductase is an essential protein that regulates the balance of antioxidants and prevents mitochondrial oxidative damage. Superoxide dismutase is a major antioxidant that can break down superoxide into less toxic molecules. Since autism was once considered an inherited disease, geneticists are preparing to study common genetic mutations that cause autism, but this has not happened yet. Although the genetic status has not changed significantly in history, vitamin D deficiency has become more and more serious worldwide in recent years, which is why the incidence of autism has increased significantly worldwide in recent years. possible. Maybe. In the US ecological research on the prevalence of autism and sun exposure, there is a negative correlation between sun exposure and the prevalence of autism in adolescents. This may be due to the rapid development of the brain during pregnancy, especially in the later stages of pregnancy. Lack of vitamin D in the body can cause autism. The point mutations and new DNA damage in autism may not be the cause of autism, but the result of the development of autism. It is caused by vitamin D deficiency, which may be caused by genetic and/or environmental factors that cause children with autism.

　　Shanling and others of the Jia Feiyong family. The research progress of vitamin D's role in autism is reviewed. Vitamins are a kind of trace organic matter necessary for humans and animals to maintain normal physiological functions. They play an important role in the growth, metabolism and development of the human body. Unlike other vitamins, vitamin D is extracted from food in a small amount, and its source mainly depends on its own synthesis. Autism is also an inflammatory disease. Vitamin D plays an anti-inflammatory effect by regulating innate and acquired immunity. Studies have shown that the pro-inflammatory chemokine MCP-1 and pro-inflammatory cytokine TNF-α in the serum of children with autism are significantly increased, indicating that autism has inflammatory changes. The serum prostaglandin (prostgrandin, PG) of children with autism is significantly increased, PG has an inflammatory effect, and calcitriol inhibits the synthesis of PG and exerts an anti-inflammatory effect. F-κB participates in abnormal signal transduction in the brain of autism, and calcitriol can also exert anti-inflammatory effects by inhibiting NF-κB. In human autoimmune diseases, there are more than 160 kinds of autoantibodies. Various brain-related autoantibodies have been found in children with autism, including anti-GAD65 and anti-MAG antibodies. The level of these autoantibodies is positively correlated with the severity of autism. This shows that autism also has autoimmune problems. Recent studies have shown that serum anti-MAG antibody levels in children with autism are negatively correlated with 25(OH)D levels.

　　Therefore, vitamin D supplementation may reduce autoantibodies in autism. The anti-autoimmune effect of vitamin D can explain the relationship between vitamin D deficiency and the prevalence of various autoimmune diseases. Vitamin D supplementation can increase the proportion of regulatory T cells in the body, produce immune tolerance, and restore normal brain function. Oxidative stress refers to the pathological process in which the body's antioxidant capacity decreases. This process leads to excessive production of active oxygen in the body or (and) increase in active oxygen in the body, thereby causing oxidative damage to cells. I will. Halicka et al. It is reported that vitamin D can directly up-regulate several antioxidant genes, such as thioredoxin reductase and superoxide dismutase. Both are involved in the antioxidant and detox process. Thioredoxin reductase is an essential protein that regulates the balance of antioxidants and prevents mitochondrial oxidative damage. Superoxide dismutase is a major antioxidant that can break down superoxide into less toxic molecules. Autism was once considered a genetic disease, so geneticists are willing to study common genetic mutations that cause autism, but it has not yet been realized. Although there has been no significant change in genetic status in history, vitamin D deficiency has become more and more serious worldwide in recent years, which may be the reason for the significant increase in the incidence of autism internationally in recent years. Maybe. In the US ecological study on the prevalence of autism and solar radiation exposure, the amount of solar radiation exposure was negatively correlated with the prevalence of autism in adolescents. This may be due to the rapid development of the brain during pregnancy, especially in the later stages of pregnancy. Lack of vitamin D in the body can cause autism. The point mutations and new DNA damage found in autism may be the result of the development of autism, not the cause of autism. This is caused by vitamin D deficiency, which may be caused by genetic and/or environmental factors that cause children with autism.