心脑血管,帕金森氏症 z-bo 2020-10-20 312

　　Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. According to the Parkinson’s Disease Foundation, 70 to 10 million people worldwide suffer from PD. In the United States, 6,000 people are diagnosed with Parkinson's disease each year, and men are 1.5 times more likely to suffer from Parkinson's disease than women.

　　PD is associated with four typical motor symptoms: tremor at rest, stiffness, slow motion, and postural instability. In addition, related non-motor symptoms include five categories: neuropsychiatric disorders, autonomy, sensory disorders, gastrointestinal disorders and sleep disorders. Typical Parkinson's disease healthcare cannot treat these symptoms that have a serious impact on quality of life. Cognitive dysfunction (CI) is one of the most common neuropsychiatric symptoms in PD patients, and cerebrovascular and cardiovascular dysfunctions are usually associated with PD. Considering that cardiac/cerebrovascular dysfunction may increase the incidence of cognitive dysfunction in PD patients, Laura Krisa of Thomas Jefferson University and other scholars have published a scientific research publication "Progress of Parkinson's Disease." ) Published this study in "English Journal" and conducted a literature review to determine the impact of ECG/Cerebrovascular dysfunction on cognitive dysfunction in PD patients (appropriate terminology, database query results, original attachment). (Please refer to the document), hoping to find better medical management methods to help PD patients improve their quality of life.

　　Scholars used autonomy, cognition, cognition, cardiovascular, Parkinson's, Parkinson's, Parkinson's disease, cerebrovascular, hypoperfusion and blood pressure as the key words of research choice in the article. We conducted a comprehensive search on PubMed and CINAHL. After screening the articles, select seven articles for analysis. The study identified five cognitive domains: mobility, attention, language fluency and memory, and visual and working memory. The main purpose of this review is to determine whether there is a clinical correlation between hypoperfusion, vascular dysfunction and cognitive impairment in PD patients. Scholars have found that there is no causal relationship between the two, but it is true, and further research is needed. Orthostatic hypotension (OH) is very common in PD patients, and up to 20% of patients show this condition. As the disease progresses, taking dopamine agonists and autonomic nervous system dysfunction, the OH behavior of PD patients is different from OH caused by age. Generally, when OH criteria and/or perfusion disorders are met, PD patients have lower cognitive test scores, and lower attention scores are significantly associated with simultaneous OH in PD patients. In other words, a decrease in the attention score indicates recognition. I know the dysfunction is more serious. Visual memory is contained in a larger and more comprehensive memory network, which includes the frontal lobe, brain wall and superior temporal lobe rotation.

　　The opinions of scholars are as follows. The cognitive decline associated with Parkinson's disease is due to hesitation of cardiovascular and cerebrovascular defects and changes in brain structure. Brain perfusion imaging is a potential and essential tool that can be used to predict and track cognitive decline in patients with Parkinson's disease.