猪瘟病毒新蛋白受体 z-bo 2020-10-20 286

　　After years of research, the innovative swine infectious disease research team of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences discovered a new swine fever virus receptor, laminin receptor. This helps researchers to improve their understanding of the mechanism of swine fever virus replication and design specific antiviral strategies for cell receptors. In addition, the discovered cell receptors can be used to reconstruct cell lines suitable for virus growth and replication. Effectively improve the production efficiency of swine fever vaccine. Therefore, the study of cell receptors is very important for the prevention and treatment of swine fever.

　　Swine fever is a major disease that seriously threatens the global pig industry. It is one of the animal diseases that the World Organization for Animal Health (OIE) must declare. China lists it as the five priorities of its medium and long-term animal disease prevention and control plan. One of the animal diseases to be controlled. The cell receptor of the virus is the "gateway" for the virus to invade the host cell and is essential for virus infection. Therefore, blocking the combination of the virus and the host cell receptor can block the invasion of the virus and its infection of the human body. According to researcher Qiu Huaji, the analysis and screening of small RNA interference technology is used to obtain a variety of candidate cell receptor molecules for swine fever virus. System identification confirmed that one of the laminin receptors is involved in the adsorption of swine fever virus to cells, and its expression level is closely related to the proliferation ability of swine fever virus, and this protein has been proved to mediate swine fever virus adsorption to host cells. body. protein. The discovery of a new swine fever receptor protein was published in the internationally renowned virology journal "Journal of Virology".