早期卵巢癌,mRNA z-bo 2020-10-20 302

　　Scientists have discovered an mRNA subunit specific to ovarian cancer. This allows early diagnosis. Ovarian cancer is a deadly disease, notorious for being difficult to diagnose and treat. Scientists at the University of California San Diego School of Medicine and Morse Cancer Center have identified six mRNA subunits (messenger RNA) in ovarian cancer cells, so that ovarian cancer can be diagnosed early. More importantly, some of these mRNA subunits can encode special proteins for new therapies. The results of this study were published in the Proceedings of the National Academy of Sciences on May 25.

　　"So far, many studies have aimed to use DNA to detect cancer," said Chris Chamberlet, the lead author of the study and an informatics expert in the Department of Genetics at the University of California, San Diego. And the project scientist) said. What is the result of tumor-specific ovarian cancer detection based on mRNA rather than DNA detection? The tumor-specific mRNA diffuses from the tumor cells to the cervix and can be collected by a conventional Pap test.

　　What is the difference between DNA and mRNA? DNA contains all the instructions necessary for life, including not only protein coding sequences, but also other sequences. mRNA is the complementary sequence of DNA and carries all the information of protein. The DNA in the nucleus transfers genetic material to mRNA, which transfers from the latter to the cytoplasm. In the cytoplasm, various organelles can recognize mRNA information and synthesize proteins at the same time. The authors show that when tumor mRNA is used to diagnose cancer, it is better to detect cancer than DNA. The reason is that cancer cells may only have one or a few copies of DNA mutation regions, but they may have hundreds to thousands of copies of mRNA mutation regions.