动物实验,埃博拉疫苗气雾剂 z-bo 2020-10-20 328

　　Researchers have reported the discovery of a new inhalable Ebola vaccine that can prevent a deadly virus in monkeys in a single dose. A paper published in the Journal of Clinical Research (Journal of Clinical Research) proved that the aerosol Ebola vaccine can activate the immune cells in the respiratory system of red-tailed monkeys and provide comprehensive protection against the vaccine.

　　The author of the article said that this is the first attempt to use aerosols to eliminate viral hemorrhagic fever in monkeys.

　　The virologist and author of the paper at the University of Texas School of Medicine in Galveston, Alexander Bukleyev, said: "The first few decades of attempts to develop an Ebola vaccine failed.") said . "This is one of the few effective vaccines."

　　However, the success of monkeys cannot guarantee that the vaccine will be effective for humans. This year, drugs that worked for monkeys did not help humans.

　　"This is a positive development," said Daniel Bausch, a virologist at Tulane University. "But this is neither groundbreaking nor discovery."

　　This new vaccine can be taken without the help of medical staff. Therefore, vaccines are particularly useful in developing countries where there is a severe shortage of doctors and nurses that prove effective for humans. This is the case in West Africa. There, the worst Ebola hemorrhagic fever in history has not yet been resolved.

　　Currently, the debate in this field is whether this round of Ebola virus will have a fundamental impact on vaccine research or is it just another panic that has been forgotten by people. "The University (University of Louisville) medical virologist Igor Lukasevich (Igor Lukasevich) said. "This aerosol vaccine is currently needed in this field. "

　　The lead author of the paper, Michelmeier, a doctoral researcher at the University of Texas Medical Branch in Galveston, was infected with body fluids. After exposure to a few drops, the respiratory tract may become an entry point for the Ebola virus. This study found that the aerosol vaccine produced more Ebola immune cells in the lungs than in the blood or spleen. Meyer said: "These cells in the lungs are the first protective barrier." "It's best to stop after infection."

　　Of the red-spotted monkeys used in this study, four had been vaccinated with aerosol, four had been vaccinated twice, and two were liquid. vaccine. The subjects of the control group were two people who had not been vaccinated. Four weeks later, all twelve monkeys were injected 1,000 times the lethal dose of Ebola virus. A little more than a week later, two non-blood-sucking monkeys were infected with the virus and euthanized, but the vaccinated monkeys were still healthy. Finally, the researchers euthanized the surviving monkeys and examined their blood and tissues. No trace of Ebola virus was found. Meyer said: "A single dose of aerosol vaccine can prevent death and serious disease in these animals."