艾滋病病毒,动物实验 z-bo 2020-10-21 330

　　German researchers reported yesterday that they are developing new methods that are expected to help patients get rid of HIV in their bodies. Animal experiments have been successful. Like other retroviruses, HIV is integrated into the human host genome to allow its genetic material to replicate during the replication process.

　　Current antiretroviral therapies can effectively prevent the growth of HIV, but they cannot eradicate this type of integrated virus. Therefore, the virus can remain dormant during the treatment and resume replication after the treatment is completed. The Dresden University of Technology in Germany issued a press release on the same day. The German University and the Heinrich Petter Institute in Hamburg cooperated with researchers to use the "Molecular Directed Evolution" method, which is an important tool for protein modification. He said that he developed a new method.

　　Brec1 recombinase. Test-tube cell specimens and experimental mouse experiments enable this recombinase to accurately identify and identify more than 90% of clinically common HIV strains, safely and accurately identify the original virus integrated from the genome of the infected cell. Indicates that it can be "cut". The so-called provirus refers to the potential viral genome located on the host chromosome. Experiments also show that this method will not damage the function of host cells and normal genes. After the original virus is removed, the immune system that has failed due to the interference of HIV genetic material is expected to return to normal. Researchers say that this method is expected to radically change the treatment of AIDS and make it completely cured. Based on current animal experiments, researchers have been approved to conduct preliminary clinical trials in AIDS patients.