黏膜细胞凋亡,过敏性疾病 z-bo 2020-10-21 350

　　When the petals die, they may "turn into spring mud to protect the flowers." But nature is not all such a virtuous circle. A new Japanese study found that after the apoptosis of animal mucosal cells, it can stimulate the immune system to "overreact" and induce autoimmune and allergic diseases. The mucous membranes such as the intestine and skin are covered by epithelial cells. When new cells are produced inside, the old cells will apoptotic and peel off, and are excreted from the body through feces, sputum and dirt on the skin. These "excluded" cells have never been found to have any effect on the body.

　　University of Tsukuba and other researchers reported in the British journal Nature Immunity that phospholipids appear on the surface after mucosal epithelial cells undergo apoptosis. This lipid is immune to the intestines, trachea and skin. A receptor protein called "CD300a" on the cell surface binds to induce an immune response, thereby inducing the deterioration of autoimmune diseases. Through animal experiments,

　　Researchers discovered that after apoptotic epithelial cells bind to the receptor protein, the number of "regulatory T cells" in mucosal tissues such as intestines, skin, and trachea is reduced, and immune cells become I find that it has a deterrent effect. Has anti-inflammatory effect.

　　The research team believes that the results of this study will help provide new treatments for a variety of autoimmune and allergic diseases in the future.