帕金森病,TMEM230基因突变 z-bo 2020-10-21 348

　　A study published by scientists in the journal Nature Genetics provided evidence of mutations in the TMEM230 gene in Parkinson's disease patients from North America and Asia. They also confirmed that the gene is mainly involved in the production of proteins packaged by the neurotransmitter dopamine in neurons. The loss of dopaminergic neurons is a decisive feature of Parkinson's disease.

　　together with the results of the study provide new clues about why Parkinson's disease occurs in the brain. These clues may indicate future treatments for this movement disorder. Today, Parkinson's disease cannot be cured, and there are few known causes.

　　Leterner Amyotrophic Lateral Sclerosis Foundation and Herbert C. Wensuke Foundation at Northwestern University Fineberg School of Medicine. Senior researcher Dr. Deepu Siddique said: "Previous research has brought Parkinson's disease into the environment, but now it is known that the only direct cause of Parkinson's disease is genetic factors." "Many genes are Parkinson's disease. It has been shown. The cause of this disease has not been confirmed, and it has been discovered that the mutation in this new fund can be confirmed in pathological and clinically confirmed disease cases.

　　About 15% of Parkinson’s disease cases are thought to be caused by genetic factors, mainly two gene mutations, called SNCA and LRRK2, Sidick said: Other genes are only related to the symptoms of tremor and paralysis, which is a movement. Common term for symptomatic neuropathy.

　　A research team from Northwestern Medical College said: The discovery that TMEM230 gene mutation can cause Parkinson's disease is the result of 20 years of cooperation and struggle by all researchers around the world.