肠道菌群,终生心血管疾病 z-bo 2020-10-21 528

　　The authoritative journal "Circulation" in the vascular field recently published an article by Professor Kelly from the School of Public Health and Tropical Medicine at Tulane University. The study aims to explore the relationship between intestinal flora and lifetime cardiovascular disease risk. The study included 55 patients with the highest risk of cardiovascular disease and 57 patients with the lowest risk of cardiovascular disease to assess the relationship between their intestinal flora and lifetime cardiovascular disease risk. The study used 16S rRNA sequencing technology to analyze the microbial DNA in the stool samples of the subjects. The alpha diversity index includes the richness and uniformity of the measurement technology, and the detection of individual species related to lifelong cardiovascular disease risk. Multivariate regression analysis was used to adjust for age, gender, and race (model 1), body mass index alone (model 2), and body mass index plus diet (model 3).

　　In the model, the ratio of each standard deviation (95% confidence interval) is increased by measuring the number of operational taxa that can be observed, the chao 1 index, and the rich-based coverage estimate, the ratio of the three indicators The ratios are 0.62 (0.39, 0.99), 0.61 (0.38, 0.98) and 0.63 (0.39, 0.99), respectively, and consistent correlations can also be obtained in models 2 and 3. In all models, compared with patients with low cardiovascular risk, patients with high cardiovascular risk have four species (Privobacterium 2, Privobacterium 7, Tyzzerella and Tyzzerella 4). The p values of the four bacteria in model 1 are: 2.12×10-3, 1.17×10-5, 4.39×10-4 and 1.51×10-4. In all models, compared with patients with low cardiovascular risk, patients with high cardiovascular risk have two species of bacteria (Alloprevotella and Catenibacterium) basically absent. The p values of these two bacteria in Model 1 were 2.96×10-6 and 1.82×10-4, respectively. Tanika N Kelly’s research demonstrated the abundance of microbial species in the body as a whole, and clarified that six of the microbial species are related to the risk of lifelong cardiovascular disease.