黄褐斑动物模型 z-bo 2020-10-22 374

　　Objective To analyze the current status of the application of chloasma animal models, to lay a good foundation for animal experiments in order to explore the theoretical knowledge of chloasma, explore new treatments, and develop new drugs, and improve the scientific, rigorous and safe treatment of chloasma.

　　Method With the theme of "chloasma", search the experimental research literature on chloasma in CNKI, Wanfang database, and Weipu database. The time ranges are "1960-2019, 1990-2019, 1979-2019". Summarize and analyze the application of animal models in the literature and the detection of related indicators.

　　Results A total of 104 experimental research documents were screened. The use of female KM mice to replicate the chloasma animal model is the most common, and the modeling method is most commonly used by ultraviolet radiation; the modeling time is 30 days the most common, and the shortest is not less than 7 days; The medication time is mostly distributed between 28 and 31 days. In the measurement of indicators, it can be divided into apparent indicators, biochemical indicators and pathological indicators. The detection of biochemical indicators is the main one, focusing on the changes of oxidation-related factors in the skin and serum.

　　Conclusion The current experimental research and theoretical discussion on chloasma are seriously out of balance with the current status of chloasma. Animal experimental research should be increased. The establishment of compound animal models and animal models with the characteristics of TCM disease is an important development direction in the future. In addition, the research on the mechanism of drug action is limited to the imbalance of oxidation and anti-oxidation in the body and on the surface of the body, ignoring related factors such as endocrine disorders. With the introduction and in-depth research of the body surface "neuro-endocrine-immune" (NEI) network In the treatment of chloasma, whether the overall and local curative effects can be exerted by regulating the NEI network in the body and on the body surface may be an important research direction in the future, which is worthy of further discussion.