高糖高脂饲料,肥胖模型 z-bo 2020-10-22 331

　　Objective To explore the effects of high-fat and high-sugar feed on fat distribution and blood biochemical indexes of Bama mini-pigs.

　　Method 14 Bama mini-pigs, 8 experimental group, susceptible mini-pigs of type 2 diabetes bred in our laboratory, fed high-fat and high-sugar diet for 30 weeks; control group 6 were fed normal diet. Thirty weeks later, the body shape coefficient, CT scan fat content, blood collection for biochemical indicators were measured, and the differences between the experimental group and the control group were compared.

　　Results After 30 weeks of high-fat and high-sugar feed, there were significant differences in body mass, body mass index (BMI) and total fat content between the experimental group and the control group (P<0.05), and the difference in visceral fat content was extremely significant (P<0.01) ; Insulin, total cholesterol, high-density lipoprotein cholesterol, and triglycerides in blood biochemical indicators are extremely different from the control group (P<0.01), and low-density lipoprotein cholesterol is significantly different from the control group (P<0.05) . In addition, serum protein and creatinine of the experimental group Bama minipigs were significantly different from the control group (P<0.05); uric acid and urea were significantly different from the control group (P<0.01), indicating that the experimental group of minipigs showed kidney damage.

　　Conclusion High-fat and high-sugar diet can cause fat accumulation in Bama mini-pigs, especially visceral fat accumulation. The blood biochemical indicators show hyperlipidemia and renal function damage.