小脑Bax基因 z-bo 2020-10-22 354

　　Objective To study the effect of psychotropic drug (heroin) on the expression of Bax gene in the cerebellum of addicted rats.

　　Method The addicted rat model was established by the continuous dose increase method, and the gene expression of Bax in cerebellar cells was detected by enzyme-linked immunosorbent assay (ELISA).

　　Results After continuously injecting heroin into rats for 7 days, the rats showed obvious withdrawal symptoms; the levels of Bax, caspase-3, and caspase-9 in the cerebellum were increased by 88.21%, 94.21%, and 87.24% respectively compared with the control group. There is a significant difference in ratio (P<0.01).

　　Conclusion The damage effect of psychotropic drugs (heroin) on brain tissue cells may be achieved by inducing the expression of Bax gene in the cerebellum and activating caspase.