肠道微生物 z-bo 2020-10-22 408

　　A few days ago, in a research report published in the international journal Scientific Reports, scientists from La Trobe University and other institutions found through research that healthy flora may have "thrive" in the intestines of individuals before they are born. . Researchers say that the body’s gut microbiome may begin to develop when the embryo grows in the womb to 5 months. The gut microbiome is essential for the survival of the body, and it is also related to digestion, brain, and heart health. , Weight control and blood sugar reduction are closely related.

　　A variety of diseases and autoimmune disorders are thought to be affected by the gut microbiome, including cancer, multiple sclerosis, and autism spectrum disorders; the findings in this article may help reveal the immune system of the developing embryo , Intestinal and brain health secrets. Using extremely strict pollution control strategies, the researchers analyzed the development of the calf's body microbiome and gastrointestinal tract before birth, and they found that the microbiome is different in different components of the fetal gastrointestinal tract.

　　In this study, the researchers completely eliminated the possibility of microbial contamination for the first time, and overturned the long-standing theory that scientists believe that fetuses develop in a sterile uterus. Researcher Franks said that the gut microbiome is important for human health. Play a key role. We all know that from infancy to adulthood, hundreds of millions of microbial cells will form an important part of the body's biological and physiological functions. They will maintain the integrity of the intestinal lining and even protect the body from The risk of disease. Up to now, the first intestinal microbiome of the baby’s body is believed to come from the mother’s birth canal or the environment in which the baby was born. This study found that the baby’s microbiome has been Reproduction in the body's intestines may change the future of fetal research and also change scientists' understanding of the mechanism by which the microbiome affects the body's immune system, intestinal tract and brain development.

　　The researchers identified 559 types of bacteria and 1,736 different archaea groups by sequencing the five components of the fetal gastrointestinal tract (ruminal fluid, rumen tissue, cecal fluid, cecal tissue, and meconium) and amniotic fluid. The distribution in the gastrointestinal tract may not be random, which indicates that the fetal body’s selection of the best microbiome actually begins in the mother’s uterus before birth. Researcher Wood said that we have found that tightly controlled microbial selection occurs along the gastrointestinal tract, and this selection is the same in every calf examined, and the researchers believe that what they have observed The reliability of microbial development indicates that the gut microbiome is essential for fetal development.

　　The results of this article are also of great significance to the research of the human body, because the human body’s gut-brain axis (intestinal microbes sending signals to the brain) plays a very critical role in the body’s development; The relationship between the nervous system and the microbiome in patients with neurodevelopmental disorders such as autism, the development of the intestine in the early life and the key role of the prenatal intestinal microbiome may have a profound impact on the health of the individual later in the body.