缓解神经性疼痛 z-bo 2020-10-23 367

　　In the United States, more than 20 million people suffer from neuropathic pain. At least 25% of these cases are classified as unexplainable and are considered underlying sensory polyneuropathy (CSPN). Although there is no information to guide doctors in choosing CSPN drugs, researchers at Mizuri University School of Medicine and MU HealthCare conducted the first prospective comparative efficacy study. In this study, we compared four drugs with different mechanisms of action in a large number of CSPN patients to determine the best drug for this situation. The study included 40 sites and recruited 402 patients over the age of 30 who were diagnosed with CSPN with a pain score of 4 or higher and a score of 10. The participants were treated with one of the four CSPN drugs: calcitonin (tricyclic antidepressant); duloxetine (serotonin norepinephrine reuptake inhibitor); prevalin (antiepileptic drug) )); or mexiretin (anti-arrhythmic drugs). The patient received the prescribed treatment for 12 weeks and was evaluated at 4, 8 and 12 weeks. Participants who reported at least 50% pain relief were considered reliable results. Patients who discontinued treatment due to side effects were also measured.

　　Dr. Richard Barron, Senior Research Fellow and Deputy Prime Minister of the University of Missouri Department of Health, said: “This study not only focuses on whether the drug can reduce pain, but also the range of side effects. These four drugs provide doctors with support for effective treatment Evidence of neuropathy. It provides and is used to support the need for newer and more effective drugs for neuropathic pain."

　　The study found that calcitonin has the highest incidence (25%). , The second lowest exit rate (38%) and the highest total utility level. Duloxetine has the second highest treatment efficiency (23%) and the lowest dropout rate (37%). Pregavalin has the lowest efficacy (15%), while methicillin has the highest smoking cessation rate (58%).

　　Barohn said: "There is no obvious good drug in this study. However, considering the efficacy and discontinuation, calcitonin and duloxetine are more effective among the four drugs. Before testing other drugs, it is recommended to use nortriptide. Or Durotin."

　　There are other non-drugs that can be used to treat peripheral neuralgia, such as gabapentin, benaracin and other sodium channel inhibitors. .. Barron said that doctors can build more databases to treat CSPN because they can conduct more comparative efficacy studies on these drugs. His goal is to establish the efficacy data of nearly 10 drugs in CSPN.