阿尔兹海默症 z-bo 2020-10-23 420

　　According to recent research, excessive alcohol consumption may be related to the onset and severity of Alzheimer's disease. This study by the Fienstein Institute of Medical Research in New York shows that excessive consumption of alcohol may cause tau protein to accumulate in the brain. Tau is often found in brain neurons. Under normal circumstances, tau protein plays a role in regulating the stability of axon microtubules. For a long time, the abnormal conformation and plaque formation of tau have been regarded as one of the main signs of Alzheimer's disease. This study attempts to clarify how excessive alcohol intake affects the conversion of tau protein from its normal form to a pathogenic form, leading to the development of Alzheimer's disease.

　　The author of the article, Dr. Max Brenner, an assistant professor at the Feinstein Institute, said: Rejuvenation is related to and related to atrophy of the cerebral cortex of diseased individuals. In addition, mouse-based studies have shown that long-term alcohol consumption can lead to phosphorylation of tau protein in hippocampal neurons, leading to memory loss in mice. The purpose of this study is to clarify the role of cold-induced RNA binding protein (CIRP), which plays an important role in the growth of tau. Brenner et al. wanted to understand the activity of cold-induced RNA binding protein (CIRP) and related forms.

　　Brenner explained: "CIRP is usually located in the nucleus. It helps regulate protein synthesis. When a cell detects a potentially harmful condition (such as alcohol exposure), it releases molecules such as CIRP to warn nearby cells. You can begin to prepare a defense system to overcome stress, warning cells to recognize extracellular CIRP when binding to specific protein receptors, and CIRP when alcohol diffuses throughout the brain. Triggered protein cascade reaction: alcohol is the main one However, the cascade reaction of eCIRP may occur under other harmful conditions. Harmful conditions can lead to the release of CIRP."

　　Alzheimer's disease is the sixth most common cause of death in the United States and the most common form of neurodegenerative dementia. There are 5.8 million people nationwide. Globally, this disease is growing endlessly. According to United Nations data, it is estimated that about 50 million people suffer from Alzheimer's disease and other forms of dementia. By 2050, the number of people affected worldwide may reach 152 million. Brenner and others believe that CIRP is blocked. Alzheimer's disease associated with heavy drinking may prove to be a viable treatment.