猪冠状病毒 z-bo 2020-10-23 376

　　A new study from the University of North Carolina at Chapel Hill suggests that porcine virus strains may also spread to humans.

　　Since its first discovery in 2016, this coronavirus strain has been called "Porcine Acute Diarrhea Syndrome Coronavirus" (SADS-CoV), which originated from bats and has infected pigs throughout China. The outbreak of this disease can cause severe economic damage in many countries.

　　The laboratory test proved the potential threat of the virus to humans. The experiment showed that SADS-CoV can effectively replicate in human liver, intestinal cells and airway cells. The survey results were published on PNAS on October 12.

　　Although it belongs to the same virus family as the B-coronavirus SARS-CoV-2 that causes human respiratory disease COVID-19, SADS-CoV is a type of coronavirus that causes gastrointestinal diseases in pigs. The virus can cause severe diarrhea and vomiting and is especially fatal to piglets.

　　SADS-COV is also different from the two circulating common cold coronaviruses in humans, HCoV-229E and HCoV-NL63.

　　article author Ralph Baric said: “Although many researchers are paying attention to β-coronaviruses such as SARS and MERS, in fact, given their potential for rapid transfer between species, α-coronaviruses also have an important impact on human health.”

　　Although it is not yet known whether SADS-CoV will affect humans, the COVID-19 pandemic can effectively remind people that many coronavirus strains found in animals may also infect humans-this effect is called the spillover effect.

　　The Baric laboratory collaborated with Caitlin Edwards, a researcher at UNC-Chapel Hill and a master of public health, to conduct this research, which shows that humans may be vulnerable to SADS-CoV spillovers.

　　Edwards, the first author of the study, tested several types of cells by infecting cells with synthetic strains of SADS-CoV to understand how high the risk of cross-species contamination is.

　　The evidence from this study shows that a variety of mammalian cells, including primary human lung and intestinal cells, are susceptible to infection. According to Edwards, unlike SARS-CoV-2, which mainly infects lung cells, SADS-CoV shows a higher growth rate in intestinal cells in the human intestine.

　　Cross-protective herd immunity usually prevents humans from infecting many of the coronaviruses found in animals. However, the test results conducted by Edwards and others indicate that humans have not yet developed such immunity to SADS-CoV.