肥胖症 z-bo 2020-10-23 422

　　Scientists at the University of Copenhagen have discovered that obesity is a brain-related disease. Specifically, because genetic mutations affect the way the brain processes sensory information and regulates diet and behavior, some people are at increased risk of obesity. In the past decade, scientists have discovered hundreds of different genetic mutations that increase a person’s risk of obesity. However, there is still much work to be done to understand how these mutations turn into obesity. Scientists at the University of Copenhagen have now identified the population of human cells involved in the development of this disease.

　　The author of the article, Associate Professor TuneHPers at the University of Copenhagen, said: "Our results provide evidence that biological processes outside of the traditional organs studied in obesity research (such as fat cells) play an important role."

　　"We have identified the types of cells in the brain that regulate the processing of memory, behavior, and sensory information related to disease development. Further studies of these areas of the brain indicate that some of us are other people. You can see why we are better than this. Fields are more prone to obesity."

　　This discovery was achieved by developing a calculation tool that combines two different data sets. The first category comes from approximately 450,000 people. Related research data for the entire genome, which compares people's health and physical attributes (such as weight) with their unique genomes. Obese patients may have a series of common genetic mutations. The second set is single-cell RNA sequencing data for more than 700 different types of mouse cell populations. This data set is because different cells express different parts of the genome. Researchers have integrated these two data sets that contain genetic fingerprints unique to each cell population, and genetic mutations closely related to obesity are controlled by 26 neural populations. We already know that the brain plays an important role in obesity by regulating the way the human body maintains energy requirements. This is the body's role in energy storage and food intake. It is done by processing signals and external signals such as the appearance and smell of food.

　　New findings indicate that a person’s obesity risk affects sensory stimulation and is directly related to diet and behavior. They also identified specific brain cell types that support learning and memory in obesity.

　　TuneHPers said: "It has been proven that this is caused by a group of active cells." The next step is to investigate how defects in parts of the brain that are traditionally known to regulate the integration of memory and sensory signals can increase our likelihood of obesity. There is increasing evidence that obesity is more complicated than previously realized. It cannot be simply attributed to the simple problem of lack of willpower.