红细胞,白细胞 z-bo 2020-10-26 302

　　A healthy adult can produce about 2 million blood cells per second, 99% of which are red blood cells that carry oxygen, and the remaining 1% are immune system platelets and various white blood cells. How to distinguish all the different types of mature blood cells from the same type of "hematopoietic" stem cells in the bone marrow has always been the focus of research, but most studies focus on 1% of immune cells.

　　It’s a little weird that I’m matching, but because red blood cells don’t have nuclei, it’s difficult to track genetic markers. Therefore, in the past few decades, the production of red blood cells has been more or less ignored. Camilla Forsburg said she is from California. Click here to get a professor of biomolecular engineering at Baskin School of Engineering at the University of Santa Cruz (University of Santa Cruz). In a new study published today in StemCelleports, the Forsburg laboratory overcame technical obstacles and performed comprehensive statistics on blood cells produced by hematopoietic stem cells. Their findings have important implications for understanding diseases such as anemia, immune system diseases, and blood cancers (such as leukemia and lymphoma).

　　Forsberg said: "We are trying to understand the balance between the production of blood cells and the immune cells that are dysregulated in many diseases." The process of hematopoietic stem cells producing mature blood cells involves multiple progenitor cell populations. I will. When the cells are fully mature, they gradually follow a specific "destiny". The main intersection of this road is between "lymphoid precursors" and "bone marrow precursors". The former produces white blood cells and the latter produces other types of white blood cells, red blood cells and platelets. Most cells in bone marrow belong to the myeloid lineage. An important finding of this new study is that all possible progenitor cells in the bone marrow produce more red blood cells than any other type of cell. This is really amazing. This is because many previous studies have found that when progenitor cells grow in vitro, their ability to produce red blood cells and platelets is limited. Forsberg said these results now appear to be caused by artificial culture conditions. She said: "Many experiments are difficult to understand because we know that the human body needs to produce a large number of red blood cells and platelets. Our results show that many of these precursor cells are large. In fact, the production of red blood cells is the default route."

　　Forsberg Lab's lead author and graduate student Scott Boyer's experiments showed a variety of researchers. Progenitor cell populations are transplanted into mice to produce red blood cells, platelets (the second largest component of blood) and immune cells. Boyer can also transplant a single precursor cell to identify the blood and immune cells it produces. By quantifying the number of mature blood cells produced from transplanted progenitor cells, the researchers found that in addition to lymphoid progenitor cells, red blood cells belong to the cell types produced by all progenitor cells. I can prove that it is the richest. Their findings led to the development of a hematopoietic differentiation model that uses red blood cells as the default pathway for all bone marrow progenitor cells.