黑色素瘤 z-bo 2020-10-28 359

　　Relaxing restrictions on the COVID-19 epidemic this summer will allow more and more Canadians to stay outdoors and enjoy the sunshine. In the latest research report published in the international journal "Nature Cancer", scientists from Magill University and other institutions have shown why men are genetically susceptible to skin cancer. In this article, the researchers identified three genes with obvious mutations on the X chromosome. Women have two X chromosomes, and men have one X and one Y chromosome. The researchers found three on the X chromosome. Among the genes with obvious mutations, only one has a special type of mutation that exists only in men.

　　Women have other types of mutations in other problematic genes, but because they have two X chromosomes (males have only one X chromosome), they have two copies of the gene. If one copy has a mutation, the other can be used. With a copy as a backup, these mutations can help researchers explain why men with melanoma have a higher risk of cancer and a lower survival rate. sexual. One of the most important risk factors for melanoma is sunlight and indoor tanning. By explaining specific gene mutations caused by exposure to ultraviolet light, scientists' advances in gene sequencing technology will help analyze melanoma in detail. Reasons behind gender differences In this study, researchers analyzed more than 1,000 melanoma cases and explained the gender differences in human melanoma risk. Subsequent researchers will continue their detailed research, including decision-making. How these mutations affect the biological characteristics of melanoma and the patient's response to immunotherapy. Researcher Watson said that immunotherapy has completely changed the treatment of many melanoma patients. Immunotherapy helps to reactivate the patient's immune system and eliminate cancer cells in the body.

　　Unfortunately, many patients do not respond to treatment, so researchers need to jointly study and understand the underlying molecular mechanisms in order to develop effective anti-cancer strategies. In addition to gender differences play an important role in the incidence of melanoma and differences in patient survival rates, individuals of different genders may respond differently to the latest therapies. There are more data to show that it exists. Current researchers want to know whether the gender differences revealed in genetic mutations can help explain the above reasons, or can help researchers better understand the genetic characteristics of multiple melanoma subtypes, or researchers. Is studying whether it will help develop new personalized anti-cancer therapies.