肝癌,肥胖 z-bo 2020-10-28 332

　　Scientists know the relationship between maternal obesity and liver cancer in the offspring of obese mothers, but the mechanism is unclear. In a new study published in the Journal of Hepatology, researchers found microRNAs in obese female mice. It seems to convey susceptibility to liver cancer and increase the risk of liver cancer in offspring and offspring.

　　One third of the world’s population is overweight or obese. This global epidemic of obesity threatens human health. Obesity increases the risk of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). In the United States, up to 50% of recently diagnosed HCCs are caused by abnormal liver metabolism (such as NAFLD). Maternal obesity directly affects the health of offspring and plays an important role in obesity and metabolic disorders. Epidemiological studies have shown that obesity is an independent risk factor for liver cancer. This new study provides insights on whether and how maternal obesity affects the incidence of tumors in offspring.

　　The researchers used diethylnitrosamine (DEN) to induce liver cancer in obese mice that ate high-fat foods, and performed RNA sequencing to determine that the gene-microRNA generational alternation did so. They found that they injected microRNA miR-27a into pregnant mice -3p not only increases liver miR-27a-3p, but also reduces the expression of Acsl1 and Aldh2 in the offspring (fetus, young, adult). Find. This also impaired the growth of HCC offspring who received DEN treatment. Maternal obesity caused by high-fat diet will make the offspring more susceptible to DEN-induced HCC. Researchers have confirmed that this sensitivity accumulates over several generations. In addition, there is an increased chance of liver cancer between two generations. For example, children born to obese mothers and grandmothers are heavier than children born to obese mothers, but grandmothers have a normal weight. The researchers also analyzed samples of human liver cancer. Researchers say their findings provide links to the mechanism between maternal obesity and the development of offspring diseases, which will help explore the treatment and prevention of fetal and developmental diseases. For pregnant women, serum miR-27a-3p levels are very important for the health of offspring and can be used as biomarkers for future diagnosis or prediction. Therefore, researchers call on all parts of the world to work together to solve the problem of human obesity for many generations in order to better solve this common problem we face.

　　This research opens a new way of cancer research at the crossroads of metabolism and epigenetics. It provides new information about how maternal stress affects her offspring and how it affects the development of liver cancer. The inheritance model is not a traditional model of intergenerational inheritance. This is multi-generation, because the sensitivity to HCC gradually increases after a few generations.