肝癌 z-bo 2020-10-28 349

　　Recently, in a research report published in the international journal Hepatology, scientists from the University of Massachusetts School of Medicine and other institutions have identified potential new therapeutic targets for hepatoblastoma through research. Hepatoblastoma is There is currently no effective treatment for a rare form of childhood liver cancer; in the article, the researchers analyzed the key role of the YAP1 oncogene in tumor survival.

　　Researcher Jordan Smith said that in this study, the researchers clarified for the first time the potential efficacy of YAP1-targeted therapy in the treatment of childhood liver cancer, and they also pointed out that the fate of cancer cells can be reversed, which may open a fan A new type of treatment door. Approximately 100 children in the United States are diagnosed with hepatoblastoma every year. For children with malignant diseases, the survival rate is low, only 27%. For these children, researchers are at a loss. In 60%-80% of patients, liver cancer is almost asymptomatic until the tumor cannot be removed by surgery.

　　Researchers usually use chemotherapy, but it is prone to have serious side effects on children, such as hearing loss or learning disabilities, and the children may need a heart or kidney transplant later. In this study, the researchers found a new method to target key genes that can control the survival and growth of tumors in hepatoblastoma, and this method is currently successful in the treatment of adult cancer; if If it can effectively play a role in the patient's body, it may be able to alleviate the children's need for chemotherapy.

　　Researchers conducted studies on animals and found that turning off the YAP1 gene may shrink more than 90% of tumors and extend the survival time of patients to more than 230 days; turning off YAP1 expression will not only promote tumor cell death, but also promote tumors The differentiation of cell subgroups can even save liver damage in mice. In the next step, researchers will develop a customized therapy that targets the liver and keep track of hepatoblastoma cells; in the end, researcher Smith said that we will continue to conduct in-depth research to develop more treatments such as hepatoblastoma. And other new therapies for childhood cancer.