肝癌 z-bo 2020-10-28 363

　　Liver cancer is the fourth most common cause of cancer death in the world and is rapidly expanding due to the "diabetes pandemic". A new study published in the Journal of Hepatology provides strong evidence that spontaneous exercise helps prevent hepatocellular carcinoma (the most common type of liver cancer) and identify related molecular signaling pathways. Fatty liver is a common disease of obesity and diabetes, and is one of the reasons for the rapid increase in the incidence of liver cancer worldwide. Every year, 800,000 people worldwide are diagnosed with this cancer. It is also the main cause of cancer deaths, with more than 700,000 people dying from cancer every year worldwide. The Australian National University said: “So far, there is no effective treatment for liver cancer (the mortality rate is close to the morbidity rate), so there is a great need for prevention of liver cancer.” (ANU) I will explain Jeffrey C, a senior researcher in the liver research group of the Department of Medicine . Dr. Farrell. "Some demographic data indicate that people who exercise regularly are less likely to develop liver cancer, but few studies have shown whether this has a real biological basis. If this is the case, few studies can confirm this protective effect The molecular mechanism of this study, and the results of these studies are inconclusive."

　　Researchers found that exercise is liver cancer in obese/diabetic mice. I researched whether it can be reduced. The gene was fed to mice, which caused obesity and type 2 diabetes, and was injected with a low-dose carcinogen at a young age. Half of the mice were able to touch the scroll wheel regularly, while the other half remained motionless. By measuring the rotation of the exercise wheel, these mice ran 40 kilometers a day. This method delayed weight gain by 3 months, but at the end of the 6-month experiment, even the exercising mice gained weight. After six months, most of the sedentary mice developed liver cancer, but the exercised mice did not. This study shows that exercise can prevent liver cancer in fatty liver mice with obesity and type 2 diabetes. Specifically, almost all obese mice injected with low-dose carcinogens will develop liver cancer within 6 months, while those that exercise regularly do not. Within the time frame of these experiments, they were completely unaffected by the development of liver cancer. Weight management does not reduce the occurrence of liver cancer. The researchers also conducted detailed mechanism studies, which partially revealed how exercise prevents liver cancer. They found that the beneficial effects of autonomous movement are exerted through molecular signaling pathways.

　　Two of them are the tumor suppressor gene p53 and the stress-activated protein kinase JNK1. The researchers first proved that the activation of JNK1 is an important factor, which can be "turned off" through exercise, and through another item of obese mice lacking JNK1. Research proves the involvement of JNK1. They also found that the activation of p53, known as the "cell guardian" and "tumor gene polisher", is important in the regulation of the cell cycle inhibitor p27, which will continue to be destined to become cancerous cells. It turns out to prevent normal growth. "Exercise has been shown to improve certain results in patients with cirrhosis of the liver. The current research on animal models is very similar to humans with fatty liver. Exercise can completely prevent liver cancer. Even if it is impossible, if it can be replicated in patients, The prognosis of patients can be significantly improved by delaying the onset of liver cancer and reducing its severity and understanding the relevant molecular pathways. Therefore, drugs and nutrients in drugs have a strong protective effect on exercise, and liver cancer in overweight diabetic patients risk.