代谢性疾病 z-bo 2020-10-29 373

　　Recently, in a research report published in the international journal PNAS, scientists from Yale University and other institutions have identified a special molecule through research that may play a role in the body’s inflammatory response to overeating. The key role is that overeating can lead to obesity, diabetes and other metabolic diseases. The results of this article show that this particular molecule may be expected as a potential therapeutic target to help control the occurrence of inflammation and metabolic diseases in the body.

　　When a person eats too much, the body will store too many calories in the form of fat in adipose tissue. As the calorie intake continues to increase, the adipose tissue will become inflamed and release fatty acids into other tissues, including the liver. And muscle tissue, which is very dangerous and very easy to cause metabolic diseases such as diabetes. Researchers now realize that overeating can lead to inflammation and metabolic diseases, but so far, they don’t know how the body’s immune cells, such as macrophages, which respond to excessive calorie intake, promote In this study, researchers discovered a signaling pathway called O-GicNAc. When a person overeats, the pathway is activated and the signaling pathway can also guide Cells limit the occurrence of inflammation in the body.